2021 North America HealthTech 200. Where are they now?

How are North America Top 200 HealthTech Startups of 2021 performing and where are they now?

Health Intelligence Unit

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May 20, 2022

In 2021, HolonIQ announced the inaugural North America HealthTech 200 — a list of the 200 most promising HealthTech startups headquartered in North America. As we open applications for the 2022 North America HealthTech 200, we take a look at where the 2021 cohort are now.

The HolonIQ North America HealthTech 200 recognises the most promising HealthTech companies based across Canada and the United States. This annual list helps to surface the innovations occurring across all parts of the market, and the teams who are supporting innovations in digital health.

Eligibility for the list covers areas including:

  • Age. The company is less than 10 years old, with few exceptions in circumstances such as bootstrapped or academic/philanthropic projects that have spun out to become commercial entities.
  • Geography. Headquartered in North America, or predominately focused on the region.
  • Status. Pre exit, ‘start-ups’, (not acquired or listed), not a subsidiary of a larger company or controlled by an investor group (e.g. via private equity buyout or controlling investment)
  • Standard Exclusions. (leading incredible innovation, but not eligible for this list).
  • Listed Companies / Private Equity Sponsors / Subsidiaries. Not eligible.
  • Mature Incumbents. The Digital Health 200 is focused on young, fast-growing companies.

Apply for the 2022 North America HealthTech 200

The North America Digital Health 200 is focused on identifying young, fast growing and innovative health technology-focused companies headquartered in North America. Applications close 31 July 2022.

Apply Now

2021 North America Health Tech 200
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HolonIQ's Scoring Fingerprint

Using the HolonIQ platform, our Intelligence Unit and market experts selected these 200 Digital Health companies out of 500+ Digital Health startups in the region, based on HolonIQ’s scoring fingerprint that includes market, product, team (including diversity), capital and momentum.

Market. The quality and relative attractiveness of the specific market in which the company competes.
Product. The quality and uniqueness of the product itself.
Team. The expertise and diversity of the team.
Capital. The financial health of the company and in particular its ability to generate or secure sufficient funding.
Momentum. Positive changes in the size and velocity of the company over time.

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Where are they now?

In 2021, HolonIQ’s Intelligence Unit identified the top 200 Digital Health startups in North America using the HolonIQ platform and HolonIQ’s scoring fingerprint that includes market, product, team (including diversity), capital and momentum. Since the start of 2022, these startups have attracted a further $3.3B in investment from 28 deals. Standout transactions include Somatus ($325M), Freenome ($290M), Kallyope ($236M), Lyra Health ($235M) and DNA Nexus ($200M). However, since a rapid start to the year the startups have found the funding markets tough going as investors tightened their belts.

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